Tesshou is your typical high school delinquent with a special skill. He has a perfect pitch. This skill enables him to hear things most people wouldn't. After saving a small dog, Tesshou realises his calling in life is to become a Vet!
Okano Hajime is an ordinary - or maybe below ordinary - girl who was forced to take care everything in the family since she was young, because her family was very poor. Hajime had five younger brothers, who were quintuplets, and they were scouted by a music company.
Ichigo Marshmallow follows the life of Nobue Ito, her younger sister Chika, and her friends Miu, Matsuri, and Ana.